Letybo is an injectable medication that contains a version of botulinum toxin A, employed to enhance the aesthetic appearance of fine lines and wrinkles.

Letybo or LetibotulinumtoxinA is a botulinum toxin type A derivative, akin to other well-known brands like Botox, Dysport, and Xeomin. The discovery of botulinum toxin traces back to the early 19th century when German physician Justinus Kerner first identified it in spoiled sausages (Erbguth, 2008).
Initially utilized to treat facial spasmodic disorders in the early 1970s, botulinum toxin was unexpectedly found to have cosmetic benefits. In 1989, Botox (onabotulinumtoxinA) was employed to address facial asymmetry due to nerve damage, leading to FDA approval for cosmetic use in 1992. Today, botulinum toxin is a widely popular cosmetic treatment globally (Gart et al., 2016).

LetibotulinumtoxinA, a type A botulinum toxin, is derived from fermenting Clostridium botulinum strain. Already a cosmetic leader in South Korea (marketed in the form of Botulax), LetibotulinumtoxinA recently gained approval in the European Union and, in June 2022, received approval for treating glabellar lines (lines between eyebrows) in Canada, broadening its global presence (Health Canada Product Monograph).

Letybo, specifically, is the result of ongoing research and development focused on refining the properties and performance of botulinum toxin for aesthetic purposes.

Letybo serves a key role in aesthetic medicine, predominantly leveraging its muscle-relaxing properties to address and mitigate the appearance of facial wrinkles and fine lines.

Similar to other formulations of botulinum toxin type A, Letybo achieves this effect through a targeted approach. By impeding nerve signals, it interferes with the muscle contractions responsible for the creation of wrinkles. This interruption results in a temporary relaxation of the treated muscles, contributing to a smoother and more youthful appearance.

Common cosmetic applications of Letybo include:

• Softening of frown lines between the eyebrows
• Diminishing the appearance of crow’s feet around the eyes
• Addressing forehead wrinkles

By strategically targeting these areas, Letybo offers individuals a non-invasive and effective solution to enhance their facial aesthetics and achieve a more refreshed look. It is important to note that the effects of Letybo are temporary, so regular treatments may be needed to maintain the results.

While Letybo shares its roots with traditional Botox, it may have unique properties that differentiate it from other formulations. Letybo stands out from other injectables due to its swift onset and enduring effectiveness.

According to Dr. Brown, the product seamlessly takes effect and spreads evenly, proving particularly effective in addressing persistent wrinkles that may not have fully responded to prior treatments. This even distribution also reduces the chances of uneven or asymmetric results.

Letybo is designed for individuals seeking non-invasive aesthetic treatments to address facial wrinkles and lines.

It may be a suitable option for those who have not achieved the desired results with other neurotoxin-based treatments or are looking for an alternative with potentially distinct characteristics.

Letybo provides relief to individuals suffering from muscular conditions such as Bruxism and cervical dystonia, chronic migraines, or excessive sweating. It can improve the quality of life for patients by reducing muscle spasms and associated discomfort.

Individuals considering Letybo should consult with qualified skin care professionals to determine its appropriateness for their specific needs and goals.

While Letybo is generally considered safe when administered by trained professionals, there are potential risks and side effects associated with its use.

Common side effects include temporary bruising, swelling, and redness at the injection site.

Other side effects include headaches, common cold symptoms, droopy eyelids, eyelid twitching, dizziness, and impaired vision for some time.

In rare cases, patients may experience muscle weakness: difficulty in swallowing, difficulty in breathing, and difficulty in speaking. In such cases, it’s important to contact your provider immediately.

It’s crucial for individuals considering Letybo treatments to consult with a qualified skincare professional to assess their suitability for the procedure and discuss potential risks based on their medical history.

Letybo, as a refined form of botulinum toxin, represents a valuable tool in the fields of aesthetic and therapeutic medicine. For those chasing a more youthful look, it smoothens wrinkles, while those with muscular conditions find relief.

A recent study has demonstrated high efficacy and a convincing safety profile of LetibotulinumtoxinA in the treatment of frown lines (Mueller, 2022).

Yet, caution is crucial. Consult skincare pros to weigh the benefits against potential risks. Letybo represents a stride forward in medical progress, promising a future where science enhances both health and beauty.

Erbguth FJ. From poison to remedy: the chequered history of botulinum toxin. J Neural Transm (Vienna). 2008;115(4):559-565. doi:10.1007/s00702-007-0728-2. Epub 2007 Apr 26. PMID: 17458494.

Gart MS, Gutowski KA. Overview of Botulinum Toxins for Aesthetic Uses. Clin Plast Surg. 2016 Jul;43(3):459-471. doi:10.1016/j.cps.2016.03.003. Epub 2016 May 4. (PubMed ID: 27363760)

Health Canada Product Monograph: Letybo (letibotulinumtoxina) powder for solution for intramuscular injection

Therapeutic Goods Administration (TGA). Letybo. https://www.tga.gov.au/resources/auspmd/letybo. Accessed 2023 Dec 12.

DrugBank. DB16820. https://go.drugbank.com/drugs/DB16820. Accessed 2023 Dec 12.

Dr. Emma Line. Letybo. https://www.dremmaline.co.uk/blog/letybo. Accessed 2023 Dec 12.

Juvae Aesthetics. Letybo Consumer Medicine Information (CMI) Summary. https://juvae.com.au/wp-content/uploads/2023/06/Letybo-CMI-Summary.pdf. Accessed 2023 Dec 12.

InStyle Australia. What is Letybo? https://instyleaustralia.com.au/beauty/what-is-letybo/. Accessed 2023 Dec 12.

Mueller DS, Prinz V, Adelglass J, Cox SE, Gold MH, Kaufman-Janette J, Nestor MS, Taylor S, Frank K. Efficacy and Safety of Letibotulinumtoxin A in the Treatment of Glabellar Lines: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Phase 3 Study. Aesthet Surg J. 2022 May 18;42(6):677-688. doi: 10.1093/asj/sjac019. PMID: 35092418.